OR2T12

OR2T12
Identifiers
Aliases	OR2T12, OR1-57, olfactory receptor family 2 subfamily T member 12
External IDs	MGI: 3030148 HomoloGene: 88370 GeneCards: OR2T12
Gene location (Human) Chr. Chromosome 1 (human) Band 1q44 Start 248,290,139 bp End 248,303,424 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B1.3 Start 58,673,778 bp End 58,679,594 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood brain dorsolateral prefrontal cortex cerebral cortex multicellular organism n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127064 257917 Ensembl ENSG00000177201 ENSMUSG00000059504 UniProt Q8NG77 Q7TRZ7 RefSeq (mRNA) NM_001004692 NM_001011760 RefSeq (protein) NP_001004692 NP_001011760 Location (UCSC) Chr 1: 248.29 – 248.3 Mb Chr 11: 58.67 – 58.68 Mb PubMed search
Wikidata
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Olfactory receptor 2T12 is a protein that in humans is encoded by the OR2T12 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

• OR2T12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.